Selected publications

Human resident liver myeloid cells protect against metabolic stress in obesity

Barreby E, Strunz B, Nock S, Naudet L, Shen JX, Johansson H, Sönnerborg I, Ma J, Urgard E, Pallett LJ, Hu Y, Fardellas A, Azzimato V, Vankova A, Levi L, Morgantini C, Maini MK, Stål P, Rosshart SP, Coquet JM, Nowak G, Näslund E, Lauschke VM, Ellis E, Björkström NK, Chen P#, Aouadi M#.

Nat Metab. 2023 Jul;5(7):1188-1203. doi: 10.1038/s42255-023-00834-7. Epub 2023 Jul 6.

Cholinergic regulation of vascular endothelial function by human ChAT+ T cells

Tarnawski L, Shavva VS, Kort EJ, Zhuge Z, Nilsson I, Gallina AL, Martínez-Enguita D, Heller Sahlgren B, Weiland M, Caravaca AS, Schmidt S, Chen P, Abbas K, Wang FH, Ahmed O, Eberhardson M, Färnert A, Weitzberg E, Gustafsson M, Kehr J, Malin SG, Hult H, Carlström M, Jovinge S, Olofsson PS.

Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2212476120. doi: 10.1073/pnas.2212476120. Epub 2023 Mar 29.

Macrophage functional diversity in NAFLD - more than inflammation

Barreby, E., Chen, P.,  Aouadi, M.

Nat Rev Endocrinol 18, 461–472 (2022). https://doi.org/10.1038/s41574-022-00675-6

Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity

Azzimato V, Chen P, Barreby E, Morgantini C, Levi L, Vankova A, Jager J, Sulen A, Diotallevi M, Shen JX, Miller A, Ellis E, Rydén M, Näslund E, Thorell A, Lauschke VM, Channon KM, Crabtree MJ, Haschemi A, Craige SM, Mori M, Spallotta F and Aouad M.

Gastroenterology. 2021 Dec;161(6):1982-1997.e11. doi: 10.1053/j.gastro.2021.08.030. Epub 2021 Aug 21.

Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce

Li Q, Hagberg CE, Cascales HS, Lang S, Hyvönen MT, Salehzadeh F, Chen P, Alexandersson I, Terezaki E, Harms MJ, Kutschke M, Arifen N, Krämer N, Aouadi M, Knibbe C, Boucher J, Thorell A, Spalding KL.

Nature Medicine. 2021 Nov;27(11):1941-1953.

A subset of Kupffer cells regulates metabolism through the expression of CD36

Blériot C, Barreby E, Dunsmore G, Ballaire R, Chakarov S, Ficht X, Simone GD, Andreata F, Fumagalli V, Guo W, Wan G, Gessain G, Khalilnezhad A, Zhang XM, Ang N, Chen P, Morgantini C, Azzimato V, Kong WT, Liu Z, Pai R, Lum J, Shihui F, Low I, Xu C, Malleret B, Kairi MFM, Balachander A, Cexus O, Larbi A, Lee B, Newell EW, Ng LG, Phoo WW, Sobota RM, Sharma A, Howland SW, Chen J, Bajenoff M, Charvet LY, Venteclef N, Iannacone M, Aouadi M and Ginhoux F.

Immunity. 2021 Sep 14;54(9):2101-2116.e6. doi: 10.1016/j.immuni.2021.08.006. Epub 2021 Aug 31.

Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes

He B*, Chen P*, Zambrano S, Dabaghie D, Hu Y, Jeansson M, Bintanel M, Wernerson A, Ernfors P, Betsholtz C, Lal M, Sandberg R, Patrakka J.

Nature Communication. 2021. Apr 9;12(1):2141.

Single-cell RNA counting at allele- and isoform-resolution using Smart-seq3

Hagemann-Jensen M, Ziegenhain C, Chen P, Ramsköld D, Hendriks GJ, Larsson A, Faridani O, Sandberg R.

Nature Biotechnology. 2020. Jun;38(6):708-714. doi: 10.1038/s41587-020-0497-0. Epub 2020 May 4.

Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance

Azzimato V*, Jager J*, Chen P*, Morgantini C, Levi L, Barreby E, Sulen A, Oses C, Willerbrords J, Xu C, Li X, Shen JX, Akbar N, Haag L, Ellis E, Wålhen K, Näslund E, Thorell A, Choudhury RP, Lauschke VM, Rydén M, Craige SM, Aouadi M.

Sci Transl Med. 2020 Feb 26;12(532).

Origins and impacts of new mammalian exons

Merkin JJ*, Chen P*, Alexis MS, Hautaniemi SK, Burge CB.

Cell Rep. 2015 Mar 31;10(12):1992-2005.

Identification of Prognostic Groups in High-Grade Serous Ovarian Cancer Treated with Platinum-Taxane Chemotherapy

Chen P, Huhtinen K, Kaipio K, Mikkonen P, Aittomäki V, Lindell R, Hynninen J, Auranen A, Grénman S, Lehtonen R, Carpén O, Hautaniemi S

Cancer Res. 2015 Aug 1;75(15):2987-98.

Evolutionary dynamics of gene and isoform regulation in Mammalian tissues

Merkin J, Russell C, Chen P, Burge CB.

Science. 2012 Dec 21;338(6114):1593-9.

Comprehensive exon array data processing method for quantitative analysis of alternative spliced variants

Chen P, Lepikhova T, Hu Y, Monni O, Hautaniemi S.

Nucleic Acids Res. 2011 Oct;39(18):e123.